上海交通大学生物微流控与微机器人课题组(Bio-MicroFluidics & Microrobotics)
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Research >> Micro/nano microrobotics >> Magnetically-driven microrobot

In this study, we have introduced a multi-level delivery strategy designed for robust and highly efficient delivery of microrobots and validated within a hierarchical vascularized organ-on-a-chip platform. Our approach combines the coordinated manipulation of a tethered microrobotic guidewire with untethered swimming microrobots, significantly enhancing the efficiency of targeted delivery within complex biological fluidic environments over extended distances. In parallel, we have engineered a hierarchical vascularized model by integrating vasculogenesis and EC-lining techniques on a single microfluidic chip, creating a comprehensive testing platform for multi-scale microrobots. This vascularized organ-on-a-chip platform demonstrates its versatility in a wide range of microrobotic applications by faithfully replicating the physiological vascular environments in-vivo, thus serving as an advanced testing platform capable of imaging, control, and biocompatibility assessment.
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Selected Publications
1. Kangyi Lu, Chenyang Zhou, Zhangjie Li, Yijun Liu, Feifan Wang, Lian Xuan and Xiaolin Wang*, Multi-level magnetic microrobots delivery strategy within a hierarchical vascularized organ-on-a-chip, Lab on a Chip,  2024, 24, 446-459.​
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