Research >> Micro/nano microrobotics >> Optically-driven microrobot
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Optical tweezers are photonic devices that exploit a tightly focused laser beam to manipulate the dielectric particles in three dimensions in a noninvasive manner. Forces imposed on particles and the corresponding deformations are in the order of piconewton (pN) and nanometre (nm), respectively. Owing to these advantages, optical tweezers have become attractive and powerful tools for cell manipulation and have been used in a variety of biological applications, such as characterizing the mechanical force in manipulating live cells, cell separation, assembling and organizing cells, analyzing the single cell dynamics upon environmental changes, and probing mechanical properties of microbiological cells, to name a few.
Also, microfluidic chip technology has provided a way for integrating a large variety of force field like optical force, which can be combined with the hydrodynamic force within the micro-channel to achieve the sophisticated cell manipulation difficult to realize by conventional setup. |
Cell sorting
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Cell fusion
Cell assembly
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Selected Publications
1. Xiaolin Wang, Shuxun Chen, Marco Kong, Zuankai Wang, Kevin D. Costa, Ronald A. Li, and Dong Sun, “Enhanced cell sorting and manipulation with combined optical tweezer and microfluidic chip technologies,” Lab on a Chip, 2011,11(21): 3656-3662.
2. Xiaolin Wang, Xue Gou, Shuxun Chen, Xiao Yan, and Dong Sun, “Cell manipulation tool with combined microwell array and optical tweezers for cell isolation and deposition,” Journal of Micromechanics and Microengineering, 2013, 23(7): 075006.
3. Xiaolin Wang, Shuxun Chen, Yu Ting Chow, Chi-wing Kong, Ronald A. Li and Dong Sun, “A microengineered cell fusion approach with combined optical tweezers and microwell array technologies,” RSC Advances, 2013, 3: 23589-23595.
4. Shuxun Chen, Jinping Cheng, Chi-wing Kong, Xiaolin Wang, Shuk Han Cheng, Ronald A. Li and Dong Sun, “Laser-induced fusion of human embryonic stem cells with optical tweezers,” Applied Physics Letters, 2013, 103(3): 033701.
1. Xiaolin Wang, Shuxun Chen, Marco Kong, Zuankai Wang, Kevin D. Costa, Ronald A. Li, and Dong Sun, “Enhanced cell sorting and manipulation with combined optical tweezer and microfluidic chip technologies,” Lab on a Chip, 2011,11(21): 3656-3662.
2. Xiaolin Wang, Xue Gou, Shuxun Chen, Xiao Yan, and Dong Sun, “Cell manipulation tool with combined microwell array and optical tweezers for cell isolation and deposition,” Journal of Micromechanics and Microengineering, 2013, 23(7): 075006.
3. Xiaolin Wang, Shuxun Chen, Yu Ting Chow, Chi-wing Kong, Ronald A. Li and Dong Sun, “A microengineered cell fusion approach with combined optical tweezers and microwell array technologies,” RSC Advances, 2013, 3: 23589-23595.
4. Shuxun Chen, Jinping Cheng, Chi-wing Kong, Xiaolin Wang, Shuk Han Cheng, Ronald A. Li and Dong Sun, “Laser-induced fusion of human embryonic stem cells with optical tweezers,” Applied Physics Letters, 2013, 103(3): 033701.